–-
Implication of calcium supplementations in health and diseases with special focus on colorectal cancer
Crit Rev Clin Lab Sci. 2024 Mar 8:1-14. doi: 10.1080/10408363.2024.2322565 PDF behind a paywall
Shahanavaj Khan 1 2, S Needa Mosvi 3, Saeed Vohra 4, Nitesh Kumar Poddar 5
Calcium is a fundamental and integrative element and helps to ensure optimal health by regulating various physiological and pathological processes. While there is substantiated evidence confirming the beneficial effects of calcium in the treatment, management, and prevention of various health conditions, including cancer, conflicting studies are imperative to acknowledge the potential negative role of calcium supplementation.
The studies on calcium supplementation showed that a specific dose can help in the maintenance of good human health, and in the control of different types of diseases, including cancer.
Calcium alone and when combined with vitamin D, emerges as a promising therapeutic option for efficiently managing cancer growth, when used with chemotherapy.
Combination therapy is considered a more effective approach for treating advanced types of colorectal cancer.
Nevertheless, several challenges drastically influence the treatment of cancer, such as
- individual discrepancy,
- drug resistance, and
- stage of cancer, among others.
Henceforth, novel preventive, reliable therapeutic modalities are essential to control and reduce the incidence and mortality of colorectal cancer (CRC). The calcium-sensing receptor (CaSR) plays a pivotal role in calcium homeostasis, metabolism, and regulation of oncogenesis. Numerous studies have underscored the potential of CaSR, a G protein-coupled receptor, as a potential biomarker and target for colorectal cancer prevention and treatment. The multifaceted involvement of CaSR in anti-inflammatory and anti-carcinogenic processes paves the way for its utilization in the diagnosis and management of colorectal cancer. The current review highlights the important role of supplemental calcium in overall health and disease, along with the exploration of intricate mechanisms of CaSR pathways in the management and prevention of colorectal cancer.
VitaminDWiki – Cancer category contains:
- Cancer
293 items Overview Cancer and vitamin D - Cancer and Vitamin D - many studies
- After Cancer Diagnosis
113 items - Bladder Cancer
28 items - Breast Cancer
259 items Overview Breast Cancer and Vitamin D - Colon Cancer
144 items Overview Cancer-Colon and vitamin D - Leukemia
19 items - Liver Cancer
17 items - Lung Cancer
55 items Overview Lung cancer and vitamin D - Lymphoma Cancer
26 items - Other Cancer
66 items - Ovarian Cancer
26 items - Pancreatic Cancer
57 items - Prostate Cancer
103 items Overview Prostate Cancer and Vitamin D - Skin Cancer
121 items Overview Suntan, melanoma and vitamin D - Childhood Cancers - Vitamin D can help - many studies
- Easiest way to treat cancer – take Vitamin D – Nov 2022
- 13 Cancers are helped by Vitamin D – Biobank July 2023
- 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
- Vitamin D prevents and treats cancer in many ways – May 2021
- Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
- Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
- Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
- 8 ways that Cancer might be prevented by Vitamin D - June 2019
- Cancer stem cells and Vitamin D - many studies
- Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
- Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
- Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
- Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
- Melanoma 25 X more likely if low vitamin D – Feb 2018
- Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018
Cancers get less Vitamin D when there is a poor Vitamin D Receptor- Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
- Cancer and the Vitamin D Receptor, a primer – Sept 2017
- Vitamin D Receptor (Cancers OR Viruses) - many studies
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Cancer (general) and VDR
23 articles - Breast Cancer and VDR
24 articles - Colon Cancer and VDR
13 articles - Prostate Cancer and VDR
7 articles - Skin Cancer and VDR
10 articles - Note some Health problems, such as some Cancers, protect themselves
by actively reducing Receptor activation
VitaminDWiki – Calcium hazards and bioavailability contains
- All items with Calcium in VitaminDWiki
226 items - Calcium from food or supplements associated with more deaths (US Cohort of 31,000 people) – April 2019
- More Calcium absorbed with more vitamin D – 6.7% more with 4000 IU – RCT March 2014
- Decrease Calcium and Increase Magnesium when increasing vitamin D
- Calcium supplements proven to NOT reduce fractures, but are proven to INCREASE heart problems – July 2015
- More than 1.4 grams of Calcium increased male death rate by 1.4 X – Sept 2018
- 10,000 IU of Vitamin D is too much if you also take Calcium supplements – RCT Sept 2018
- Calcium Essential to Limit Osteoporosis but Avoid Excess, Say Europeans - Nov 2017
- Hypercalcemia can result from excess Vitamin D (if not reduce Ca or increase water) Oct 2016
- Must balance co-factors when increasing vitamin D 500 Ca, 500 Mg - which has the following concept graph
XX+ VitaminDWiki Calcium pages have CANCER in the title
This list is automatically updated
Items found: 8Calcium often reduces the risk of health problems such as Colorectal Cancer – March 2024Printer Friendly Follow this page for updates1090 visitors, last modified 10 Mar, 2024, This page is in the following categories (# of items in each category)
- Breast Cancer and VDR